Plug Flow Crystallizer

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A continuous crystallizer exhibiting plug flow and low attrition of crystals

Inside a Plug Flow Crystallizer (PFC), a shaft with uniquely arranged blades rotates within a shell. The product flows through in a nearly plug flow manner under uniform and gentle agitation. Multiple heating /cooling sections provide controlled temperature gradients. Gentle agitation minimizes breakage of crystals. It can have several openings along its length for addition of seeds or anti-solvents.

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FEATURES

    • Runs continuously, residence time from 0.5 hours to 10 hours is possible
    • Can be operated in cooling or evaporative mode.
    • Crystallization with anti-solvents is possible
    • Can be used with high percentage of solids in slurries
    • Good control on concentration profile to avoid uncontrolled nucleation
    • Plug flow conditions and low attrition between crystals
    • Easy conversion from batch operation to continuous operation

Applications

    • Bulk drugs and intermediates
    • Fine chemicals
    • Inorganic and organic salts
    • Any application where close crystal size distribution is desired

CRYSTALLIZER

CASE STUDIES

Improved crystal size distribution using a Plug Flow Crystallizer

Application Brief

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